Single Cell Screening Rethought

Important data can be gained at any stage of biological experiments. The end result might be what you are mainly after, but immediate reactions of the cells to a drug or observing cell-cell interaction on the single cell level might be an insight not accessible with other techniques yet. The CellShepherd^® allows for the microscopic analysis of processes inside the microwells at any time: take snapshots, videos and time-lapse series to follow the development of your experiment as detailed as you wish.

The most critical factor of any study are reliable and reproducible measurements. Avoiding contamination is key and can only be guaranteed by inert and stable materials. However, many systems rely on using non-inert materials thus risking the diffusion of reagents and drugs. These effects may be small but can compromise or even devaluate your whole experiment. ARRALYZE arrays consist entirely of glass, one of the most inert materials in bio sciences.

Our glass wells require very low sample volumes ranging of picoliters to nanoliters, which reduces use of expensive reagents per experiment. The well dimensions have an ideal fit to the size of individual cells and cell clusters, making it easy to find and track cells - a critical feature for high-throughput experiments. The low footprint of the glass arrays allows for a greater number of experiments per area, reducing the overall footprint per experiment. This way you can increase the statistical significance of your experiments in a very economical manner.

With standard assays, your experiments have to be adapted to existing equipment. We believe that the equipment should follow the design of your experiment. With ARRALYZE you can tailor the size and shape of the wells to your cell type and the requirements of the assay. You can also study single cells, clusters of cells or co-cultures in different arrangements. Besides the well size and shape you can of course also pick the format of your glass array such as the microscope slide format.