UC Berkeley Researchers Utilize Arralyze Glass Microwells for Advanced Single-Cell Nuclear Analysis

A publication from researchers at UC Berkeley, led by Amy Herr, demonstrates how Arralyze's glass slides enable precise manipulation of cellular components at the microscale. The team developed a microfluidic device called VacTrap that facilitates the transfer of nuclei from individual cells while maintaining spatial organization and cellular integrity.

A graphic of multiple papers above each other. The front page shows a page from the publication of UC Berkeley using the Arralyze nanowell chips. The text on the graphic states: Publication - Single-cell Organelle Extraction with Cellular Indexing

Key Research Advancements

The study, supported by the National Institutes of Health and the Chan-Zuckerberg Biohub, showcases a multilayer approach to single-cell analysis that addresses several longstanding challenges in the field:

Simultaneous processing of hundreds of individual cells

Preservation of spatial information between cells and their extracted nuclei

Rapid transfer of nuclear material (completed in 3-5 minutes)

Maintenance of nuclear morphology and integrity throughout the process

Arralyze Glass Technology: The Foundation for Precision

Central to this research breakthrough are Arralyze's 100-μm diameter, 400-μm thick through-hole glass slides. The publication specifically highlights the advantages of our specialized glass technology:

Low autofluorescence and high optical transparency in the visible region, critical for accurate fluorescence microscopy

Precise dimensions achieved through the Laser Induced Deep Etching process

Reliable structural integrity that supports complex multilayer device assembly

The researchers acknowledge: "We appreciate Arralyze's generous support through the donation of through-hole glass slides for the initial concept development of VacTrap." This collaboration highlights how specialized materials drive scientific innovation.

Implications for Single-Cell Analysis

This work demonstrates how Arralyze's precision-engineered glass platforms can serve as fundamental building blocks for next-generation cellular analysis tools. The approach has potential applications across genomics, proteomics, and integrated multi-omics research.

For scientists and biotech professionals working in single-cell analysis, microfluidics, or precision diagnostics, this publication illustrates how high-quality substrate materials can enable methodological breakthroughs.

Read the full publication to explore how Arralyze's glass technology is helping advance the frontiers of cellular research.

READ THE FULL PUBLICATION