Arralyze Glass Nanowells Featured in Glaucoma Research
The Research Breakthrough
Glaucoma affects millions worldwide and is often associated with elevated intraocular pressure due to increased resistance in the eye's drainage system. The researchers focused on specialized cellular structures called CLANs, which are more prevalent in glaucomatous eyes.
Using our glass chip containing hundreds of nanowells, the research team was able to:
Observe the real-time formation and disassembly of CLANs in living cells
Document the surprising finding that while CLAN induction required days of treatment, the actual assembly occurred within minutes
Measure precise persistence times of these structures after treatment withdrawal
Successfully increase CLAN incidence from less than 1% to approximately 50% through combined enrichment methods
How Arralyze Technology Made a Difference
Our glass chip design provided the perfect platform for this research by offering:
Stable, controlled microenvironments for long-term cell observation
Precise containment of cells for tracking individual cellular responses
Optimal optical properties for high-resolution fluorescence imaging
Compatibility with standard microscopy setups and incubation systems
Defect-free nanowells for reliable and reproducible experiments
Miniaturized design that conserves reagents and reduces costs
The researchers specifically noted that cell behaviors on our nanowells were comparable to traditional glass dishes while offering enhanced experimental capabilities.
This publication shows how Arralyze's precision-engineered nanowell technology is helping advance our understanding of complex cellular mechanisms in disease. We're proud to support innovative research that may ultimately lead to new treatments for sight-threatening conditions like glaucoma.
Further Information
